![]() description : The Mouse ASGR1/ASGPR1 Antibody from R&D Systems is a rat monoclonal antibody to ASGPR1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. application : western blot, ELISA, immunohistochemistry. The protein encoded by this gene is the more abundant major subunit. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. These antibodies target ASGR1 in Human, Mouse, Rat and Porcine samples. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. Mouse Reactivity: Rat Host Species: Rabbit Isotype: IgG Antibody Type: Polyclonal Antibody Research Area: Cell Biology. This antibody functions as an ELISA capture antibody when paired with Rat Anti-Mouse ASGR1/ASGPR1 Monoclonal Antibody (Catalog MAB27552 ). This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. Anti-ASGR1 Antibody (CAB13279) from Assay Genie is a high quality antibody with reactivity against Human, Mouse, Rat and validated in WB applications. This gene encodes a subunit of the asialoglycoprotein receptor. Molecular Function:protein binding protein homodimerization activity metal ion binding asialoglycoprotein receptor activity carbohydrate bindingīiological Process: receptor-mediated endocytosis cellular response to extracellular stimulus The receptor then returns to the cell membrane surface.Ĭhromosomal Location of Human Ortholog: 17p13.2Ĭellular Component: integral to plasma membrane extracellular region After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor recognizes terminal galactose and N-acetylgalactosamine units. Asialoglycoprotein receptor 1 ASGR1 ASGPR CLEC4H1 Hs.12056 ĪSGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. ![]()
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